And if you have flex duct and/or fiberglass ductboard in your home- the last thing you want is a big brush or anything abrasive running through it. Even high-pressure air can erode ductboard so I wouldn’t clean it with anything. If it becomes contaminated, get rid of it and install real ductwork. If your ductwork is accessible in the basement – the best thing to do is take it down and manually clean it if it’s full of junk. It’s not going to cost a nickel more to do that than to pay $500-1000 for a ‘duct cleaning machine” AKA big blower and vacuum – to do the job.
Most organizations concerned with duct cleaning, including EPA, NADCA, NAIMA and the Sheet Metal and Air Conditioning Contractors' National Association (SMACNA) do not currently recommend the routine use of sealants to encapsulate contaminants in any type of duct. Instances when the use of sealants to encapsulate the duct surfaces may be appropriate include the repair of damaged fiber glass insulation or when combating fire damage within ducts. Sealants should never be used on wet duct liner, to cover actively growing mold, or to cover debris in the ducts, and should only be applied after cleaning according to NADCA or other appropriate guidelines or standards.
Some research suggests that cleaning heating and cooling system components (e.g., cooling coils, fans and heat exchangers) may improve the efficiency of your system, resulting in a longer operating life, as well as some energy and maintenance cost savings. However, little evidence exists that cleaning only the ducts will improve the efficiency of the system.