One of the best ways to know if your ducts or vents need to be cleaned is to just check them. Your eyes will be able to check for indications of mold, dust or pollen buildup. You might also be able to smell the presence of mold, which would be a clear indicator. Ductwork will have some buildup of dust, since the return registrars pull air back in. However, this doesn't mean your ducts have too much debris, and you can easily clean them with a duster or vacuum.
The final cost of this service is best determined after a professional inspection. Many air duct cleaning companies build their prices based on individual services, while others offer package pricing which includes such components as the air conditioning and furnace. The following estimates can give you an idea of prices to expect for various services.
Some research suggests that cleaning heating and cooling system components (e.g., cooling coils, fans and heat exchangers) may improve the efficiency of your system, resulting in a longer operating life, as well as some energy and maintenance cost savings. However, little evidence exists that cleaning only the ducts will improve the efficiency of the system.