NADCA and EPA both have good points. Although, organizations are made to make money. Common sense and looking at NADCA and EPA pre-checklist. If you don't see it in the check list, you don't have to do it! But, if you do, look up Diamond certified co.s and the BBB. Beware of bait and switch scams, $60 vents and the like coupons which claim to help all for the measley sum of $79.00 bucks.
What about ringworm? If the fungus is as contagious as doctors warn, and the spores can live several months, doesn’t it make sense to spray some sort of fungus killer into the HVAC system to kill the spores that it has sucked in from the air? Duct cleaning would not be helpful at all here; these spores are microscopic and it could actually spread them further. But given how severely contagious ringworm is, body and especially scalp, does anyone make an aerosol product that will clean the system and kill the fungus? One the resident can use, not call an HVAC company; you can’t do that when you are in an apartment. I hear it’s not the same as mold, it is much more difficult. Truth?
Did you know that cleaning your ducts and vents can help airflow and increase energy efficiency? According to the Environmental Protection Agency (EPA), keeping your air ducts and vents clear can increase energy efficiency and indoor air quality. While the cost to clean ducts and vents might sound high, the benefits to homeowners–especially those sensitive to allergens–is worth considering.

in response to this reply " should your ducts be cleaned", i have to politely correct the person who answered this. you are not using common sense. first, most of the country uses metal duct work, so for you to say what you did, is wrong. second, the duct system in a house is a circulatory system. that means it draws air into the furnace, it gets filtered, and then it is blown out into the house to heat or cool. So, obviously that air is being brought into the house from somewhere right? Yes, its coming from the outside where there are many allergens and dust particles . For you to says that about whether a duct system is sealed or not, makes no difference. The air is coming from somewhere right? It has to originate from somewhere right? Just look on top of your cieling fan. If there is a bunch of dust up there, then there is obviously a bunch in your ducts. And the duct air is being circulated every day, and every hour through your house. Its simple, dust collects everywhere in your house. Imagine if you never dusted your shelves, or tv? There would be a ton of dust after a while. Well, now think about the air in the duct system. Of course theres gonna be a ton of dust in there. For you to say that it is not benififcial to clean the ducts, is plain ignorant. 90% of the air we breathe is in our household. Wouldnt you want that air to be as dust and allergen free? I could go on for hours about the benifits of duct cleaning, but i just wanted to make a quick point that the person whose says it is not benificial to clean them, is not using common sense. Not to mention, giving the people who clean ducts for a living, a bad name. Use your head .

All of the products discussed above are registered solely for the purpose of sanitizing the smooth surfaces of unlined (bare) sheet metal ducts. No products are currently registered as biocides for use on fiber glass duct board or fiber glass lined ducts, so it is important to determine if sections of your system contain these materials before permitting the application of any biocide.
The amount of debris or mold present in your system could certainly ratchet up the overall price. The cost of mildew removal is around $0.07-0.08 per square foot, on top of your initial cost, according to Blue Book. Removing these elements involves added time, special equipment and even special chemicals. In fact, you may be referred to a specialist if mildew and mold is too severe.
Some research suggests that cleaning heating and cooling system components (e.g., cooling coils, fans and heat exchangers) may improve the efficiency of your system, resulting in a longer operating life, as well as some energy and maintenance cost savings. However, little evidence exists that cleaning only the ducts will improve the efficiency of the system.