When you hire someone to put up wallpaper or build a fence, it's easy to see whether it's a good job. But with services like air duct cleaning, there's much more risk of fraud because the homeowner can't easily check the work. A disreputable company may not have the proper equipment to do a quality air duct cleaning job, may overcharge you, may leave the ducts dirty or filled with debris and may even do costly damage to your home's HVAC system. Some companies entice you with very low offers, such as $59 for a whole-house cleaning, then pile on extra charges. 
I am NADCA Certified Air Systems Cleaning Specialist. Over the years I have learned on simple answer to this questions: there air duct cleaners and there are pretenders. There will be no benefit at all if you use on the very cheap pretender because they will not really clean anything. On the other hand if you call a qualified air duct cleaner with a NADCA Certification you will, like 99% of my customers, report improvement with your respiratory problems, you will see less dust and the job will pay for itself with energy savings and repair prevention.
Yes everyone should get all their ductwork cleaned, because it does help, incame down with major allergies and had serval operations on my sinues because of this problem of air quality and dust, plus i almost died from one of the operations, i was suffering so much. Yes you can seal your duct system by buyind duct seal t instead of tape to tape all the corners of the vent system, tape wears out and gets brittle, the sealant you can buy at home depot, and you just brush it all over the connections of your ductwork, it comes in a container and it is like a thick paste and dries making a good seal for your ductwork.
You should be aware that although a substance may look like mold, a positive determination of whether it is mold or not can be made only by an expert and may require laboratory analysis for final confirmation. For about $50, some microbiology laboratories can tell you whether a sample sent to them on a clear strip of sticky household tape is mold or simply a substance that resembles it.
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